kinesin-1

Function: - form of kinesin facilitating fast axonal transport of APP Expression: - KLC1 may be found in neurons in place of KLC2.

Properties

COMPARTMENT: cytoplasm MOTIF: active site MOTIF: adenine nucleotide-binding site guanine nucleotide-binding site SUBUNITS: kinesin heavy chain (2) MOTIF: kinesin motor domain SITE: 1-328 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 85-92 binding site FOR-BINDING-OF: microtubule active site SITE: N-TERMINAL MOTIF: P-loop {N-TERMINAL} FOR-BINDING-OF: adenosine triphosphate binding site FOR-BINDING-OF: microtubule domain MOTIF: alpha helix coiled coil coiled coil {329-914} binding site SITE: C-TERMINAL EFFECTOR-BOUND: kinesin light (beta) chain BOUND-VIA: binding site Globular {915-963} kinesin light chain 2 (2) MOTIF: coiled coil {78-143} tetratricopeptide repeat {198-231} tetratricopeptide repeat {240-273} tetratricopeptide repeat {282-315} tetratricopeptide repeat {324-357} tetratricopeptide repeat {366-399} Ser phosphorylation site {S445} tetratricopeptide repeat {449-482} Ser phosphorylation site {S507} Ser phosphorylation site {S508} Ser phosphorylation site {S582}

References

- Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature. 2001 Dec 6;414(6864):643-8. PMID: 11740561

Components

kinesin heavy chain (ubiquitous kinesin heavy chain, UKHC, KIF5B KNS KNS1) kinesin light chain 2 (KLC2)