kinesin heavy chain (ubiquitous kinesin heavy chain, UKHC, KIF5B KNS KNS1)

Function: - microtubule-dependent motor required for normal distribution of mitochondria & lysosomes (putative) - kinesin oligomer composed of two heavy chains & two light chains - interacts with GRIP1 (putative) - interacts with SYBU Structure: - composed of three structural domains: a) large globular N- terminal domain responsible for motor activity of kinesin (hydrolyzes ATP & binds microtubule) b) central alpha-helical coiled coil domain that mediates heavy chain dimerization c) small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles & membranous organelles - belongs to the kinesin-like protein family, kinesin subfamily - contains 1 kinesin-motor domain Compartment: - uniformly distributed between soma & neurites in hippocampal neurons (putative)

General

kinesin family 5 (Kif5) kinesin heavy (alpha) chain

Properties

SIZE: entity length = 963 aa MW = 110 kD COMPARTMENT: cytoplasm MOTIF: kinesin motor domain SITE: 1-328 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 85-92 binding site FOR-BINDING-OF: microtubule active site SITE: N-TERMINAL MOTIF: P-loop {N-TERMINAL} FOR-BINDING-OF: adenosine triphosphate binding site FOR-BINDING-OF: microtubule domain MOTIF: alpha helix coiled coil coiled coil {329-914} binding site SITE: C-TERMINAL EFFECTOR-BOUND: kinesin light (beta) chain BOUND-VIA: binding site Globular {915-963}

Database Correlations

OMIM 602809 UniProt P33176 Pfam PF00225 Entrez Gene 3799 Kegg hsa:3799

References

UniProt :accession P33176