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kinesin heavy chain 2A (Kif2A, kinesin family protein 2, HK2, KIF2, KNS2)
Function:
- plus end-directed microtubule-dependent motor required for normal brain development
- may regulate microtubule dynamics during axonal growth
- implicated in formation of bipolar mitotic spindles
- has microtubule depolymerization activity
Structure:
- belongs to the kinesin-like protein family, MCAK/KIF2 subfamily
- contains 1 kinesin-motor domain
- phosphorylated on Ser-579 (putative)
Compartment:
- cytoplasm (putative)
- centrosome
Alternative splicing: named isoforms=4
Pathology:
- HeLa cells lacking KIF2A show asymmetric or monopolar mitotic spindles
- osteosarcoma cells (U2OS) lacking KIF2A or KIF2B show disorganised or monopolar mitotic spindles Kif2 gene cloned from follicular B-cell lymphoma cells treated with synthetic retinoid HPR. (see OMIM :accession 602591)
Related
kinesin-2
General
kinesin family protein
kinesin heavy (alpha) chain
phosphoprotein
Properties
SIZE: entity length = 706 aa
MW = 80 kD
COMPARTMENT: cytoplasm
MOTIF: Globular {1-217}
MOTIF: Thr phosphorylation site {T78}
Ser phosphorylation site {S140}
kinesin motor domain
SITE: 218-552
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 313-320
binding site
FOR-BINDING-OF: microtubule
coiled coil {660-699}
Database Correlations
OMIM 602591
UniProt O00139
Pfam PF00225
Entrez Gene 3796
Kegg hsa:3796
References
- OMIM :accession 602591
- UniProt :accession O00139