kinesin-like 1 protein; kinesin-like protein KIF11; kinesin family member 11; kinesin-related motor protein Eg5; kinesin-like spindle protein HKSP; thyroid receptor-interacting protein 5 (KNSL1, KIF11, TRIP5, EG5)

Function: - motor protein required for establishing a bipolar spindle - blocking of KIF11 prevents centrosome migration & arrests cells in mitosis with monoastral microtubule arrays - interacts with the thyroid hormone receptor in the presence of thyroid hormone - phosphorylated exclusively on Ser during S phase, but on both Ser & Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase) - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - belongs to the kinesin-like protein family, BimC subfamily - contains 1 kinesin-motor domain

General

kinesin family protein phosphoprotein thyroid hormone receptor interacting protein (TRIP)

Properties

SIZE: entity length = 1056 aa MW = 119 kD COMPARTMENT: cytoplasm MOTIF: kinesin motor domain SITE: 16-363 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 105-112 binding site FOR-BINDING-OF: microtubule coiled coil {364-480} MOTIF: Thr phosphorylation site {T458} coiled coil {736-763} Thr phosphorylation site {T926} Ser phosphorylation site {S931}

Database Correlations

OMIM 148760 UniProt P52732 Pfam PF00225 Entrez Gene 3832 Kegg hsa:3832

References

UniProt :accession P52732