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CD30; tumor necrosis factor receptor superfamily member 8; CD30L receptor; lymphocyte activation antigen CD30; KI-1 antigen (TNFRSF8, D1S166E)

Function: - receptor for TNFSF8/CD30L - may play a role in the regulation of cellular growth & transformation of activated lymphoblasts - regulates gene expression through activation of NF-kappa-B - interacts with TRAF1, TRAF2, TRAF3 & TRAF5 - phosphorylated on Ser & Tyr Structure: contains 6 TNFR-Cys repeats Compartment: - isoform long: cell membrane - isoform short: cytoplasm Alternative initiation: named isoforms=2 Expression: - granulocytes - plasma cells - activated T cells & B cells - NK cells Pathology: - expressed in: a) lymphocytes infected with HIV, HTLV-1, EBV, HHV8 or hepatitis B virus b) infectious mononucleosis c) Reed-Sternberg cells - CD30 is a cell surface marke for Hodgkin's disease d) anaplastic large cell lymphomas ~90% e) lymphomatoid papulosis f) peripheral T cell lymphomas g) embryonal carcinoma Pharmacology: - target of monoclonal antibody brentuximab, component of antineoplastic agent brentuximab vedotin used for treatment of Hodgkin's lymphoma & systemic anaplastic large cell lymphoma

Related

CD30 Ag in tissue CD30 cells in specimen Hodgkin's disease (Hodgkin's lymphoma)

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen tumor necrosis factor [TNF] receptor family

Properties

SIZE: MW = 64 kD entity length = 595 aa COMPARTMENT: plasma membrane MOTIF: cysteine-rich region {N-TERMINAL} MOTIF: cysteine residue {X+0} MODIFICATION: cysteine residue {X+14} N-glycosylation site cysteine residue {X+14} MODIFICATION: cysteine residue {X+0} cysteine residue {X+16} MODIFICATION: cysteine residue {X+29} cysteine residue {X+19} MODIFICATION: cysteine residue {X+34} cysteine residue {X+29} MODIFICATION: cysteine residue {X+16} cysteine residue {X+34} MODIFICATION: cysteine residue {X+19} cysteine-rich region {complement receptor type 2 COMPARTMENT: cellular membrane MOTIF: signal sequence {1-20} Sushi domain {21-659} (10) MOTIF: cysteine residue {C23} MODIFICATION: cysteine residue {C65} cysteine residue {C51} MODIFICATION: cysteine residue {C82} cysteine residue {C65} MODIFICATION: cysteine residue {C23} cysteine residue {C82} MODIFICATION: cysteine residue {C51} Sushi domain {660-716} MOTIF: cysteine residue {C662} MODIFICATION: cysteine residue {C699} N-glycosylation site {N682} cysteine residue {C685} MODIFICATION: cysteine residue {C714} cysteine residue {C699} MODIFICATION: cysteine residue {C662} cysteine residue {C714} MODIFICATION: cysteine residue {C685} Sushi domain {717-781} MOTIF: cysteine residue {C719} MODIFICATION: cysteine residue {C762} cysteine residue {C748} MODIFICATION: cysteine residue {C779} cysteine residue {C762} MODIFICATION: cysteine residue {C719} cysteine residue {C779} MODIFICATION: cysteine residue {C748} Sushi domain {786-845} MOTIF: cysteine residue {C788} MODIFICATION: cysteine residue {C830} N-glycosylation site {N800} cysteine residue {C816} MODIFICATION: cysteine residue {C843} N-glycosylation site {N823} cysteine residue {C830} MODIFICATION: cysteine residue {C788} cysteine residue {C843} MODIFICATION: cysteine residue {C816} Sushi domain {849-909} MOTIF: cysteine residue {C851} MODIFICATION: cysteine residue {C894} N-glycosylation site {N861} cysteine residue {C880} MODIFICATION: cysteine residue {C907} cysteine residue {C894} MODIFICATION: cysteine residue {C851} cysteine residue {C907} MODIFICATION: cysteine residue {C880} Sushi domain {910-970} MOTIF: N-glycosylation site {N911} cysteine residue {C912} MODIFICATION: cysteine residue {C955} cysteine residue {C941} MODIFICATION: cysteine residue {C968} cysteine residue {C955} MODIFICATION: cysteine residue {C912} cysteine residue {C968} MODIFICATION: cysteine residue {C941} transmembrane domain {972-999} Tyr phosphorylation site {Y1029}} MOTIF: cysteine residue {X+0} MODIFICATION: cysteine residue {X+14} cysteine residue {X+14} MODIFICATION: cysteine residue {X+0} cysteine residue {X+16} MODIFICATION: cysteine residue {X+29} cysteine residue {X+19} MODIFICATION: cysteine residue {X+34} N-glycosylation site cysteine residue {X+29} MODIFICATION: cysteine residue {X+16} cysteine residue {X+34} MODIFICATION: cysteine residue {X+19} cysteine-rich region {integrin alpha-M COMPARTMENT: cellular membrane MOTIF: signal sequence {1-16} FG-GAP {31-84} MOTIF: cysteine residue {C66} MODIFICATION: cysteine residue {C73} cysteine residue {C73} MODIFICATION: cysteine residue {C66} FG-GAP {85-163} MOTIF: N-glycosylation site {N86} cysteine residue {C105} MODIFICATION: cysteine residue {C123} cysteine residue {C123} MODIFICATION: cysteine residue {C105} VWFA domain {164-350} MOTIF: N-glycosylation site {N240} FG-GAP {337-400} MOTIF: N-glycosylation site {N391} FG-GAP {401-452} FG-GAP {454-515} MOTIF: Ca+2-binding site SITE: 465-473 N-glycosylation site {N469} FG-GAP {517-575} MOTIF: Ca+2-binding site SITE: 529-537 FG-GAP {580-632} MOTIF: Ca+2-binding site SITE: 592-600 cysteine residue {C654} MODIFICATION: cysteine residue {C711} N-glycosylation site {N692} N-glycosylation site {N696} cysteine residue {C711} MODIFICATION: cysteine residue {C654} N-glycosylation site {N734} cysteine residue {C770} MODIFICATION: cysteine residue {C776} cysteine residue {C776} MODIFICATION: cysteine residue {C770} N-glycosylation site {N801} cysteine residue {C847} MODIFICATION: cysteine residue {C864} cysteine residue {C864} MODIFICATION: cysteine residue {C847} N-glycosylation site {N880} N-glycosylation site {N900} N-glycosylation site {N911} N-glycosylation site {N940} N-glycosylation site {N946} N-glycosylation site {N978} N-glycosylation site {N993} cysteine residue {C998} MODIFICATION: cysteine residue {C1022} N-glycosylation site {N1021} cysteine residue {C1022} MODIFICATION: cysteine residue {C998} cysteine residue {C1027} MODIFICATION: cysteine residue {C1032} cysteine residue {C1032} MODIFICATION: cysteine residue {C1027} N-glycosylation site {N1044} N-glycosylation site {N1050} N-glycosylation site {N1075} transmembrane domain {1105-1128} GFFKR {1131-1135}} MOTIF: cysteine residue {X+0} MODIFICATION: cysteine residue {X+14} cysteine residue {X+14} MODIFICATION: cysteine residue {X+0} cysteine residue {X+16} MODIFICATION: cysteine residue {X+29} cysteine residue {X+19} MODIFICATION: cysteine residue {X+34} cysteine residue {X+29} MODIFICATION: cysteine residue {X+16} cysteine residue {X+34} MODIFICATION: cysteine residue {X+19} cysteine-rich region {integrin alpha-X COMPARTMENT: cellular membrane MOTIF: signal sequence {1-19} FG-GAP {34-87} MOTIF: N-glycosylation site {N61} cysteine residue {C69} MODIFICATION: cysteine residue {C76} cysteine residue {C76} MODIFICATION: cysteine residue {C69} consensus repeat {88} SEQUENCE-IS: FG-GAP N-glycosylation site {N89} cysteine residue {C108} MODIFICATION: cysteine residue {C126} cysteine residue {C126} MODIFICATION: cysteine residue {C108} VWFA domain {165-351} N-glycosylation site {N392} consensus repeat {401} SEQUENCE-IS: FG-GAP FG-GAP {402-453} FG-GAP {455-517} MOTIF: Ca+2-binding site SITE: 466-474 FG-GAP {518-576} MOTIF: Ca+2-binding site SITE: 530-538 FG-GAP {581-633} MOTIF: Ca+2-binding site SITE: 593-601 cysteine residue {C655} MODIFICATION: cysteine residue {C712} N-glycosylation site {N697} cysteine residue {C712} MODIFICATION: cysteine residue {C655} N-glycosylation site {N735} cysteine residue {C771} MODIFICATION: cysteine residue {C777} cysteine residue {C777} MODIFICATION: cysteine residue {C771} cysteine residue {C848} MODIFICATION: cysteine residue {C863} cysteine residue {C863} MODIFICATION: cysteine residue {C848} N-glycosylation site {N899} N-glycosylation site {N939} cysteine residue {C998} MODIFICATION: cysteine residue {C1022} cysteine residue {C1022} MODIFICATION: cysteine residue {C998} cysteine residue {C1027} MODIFICATION: cysteine residue {C1032} cysteine residue {C1032} MODIFICATION: cysteine residue {C1027} N-glycosylation site {N1050} transmembrane domain {1108-1128} GFFKR {1131-1135}} MOTIF: cysteine residue {X+0} MODIFICATION: cysteine residue {X+14} cysteine residue {X+14} MODIFICATION: cysteine residue {X+0} cysteine residue {X+16} MODIFICATION: cysteine residue {X+29} cysteine residue {X+19} MODIFICATION: cysteine residue {X+34} cysteine residue {X+29} MODIFICATION: cysteine residue {X+16} cysteine residue {X+34} MODIFICATION: cysteine residue {X+19} cysteine-rich region {CR5} MOTIF: cysteine residue {X+0} MODIFICATION: cysteine residue {X+14} cysteine residue {X+14} MODIFICATION: cysteine residue {X+0} cysteine residue {X+16} MODIFICATION: cysteine residue {X+29} cysteine residue {X+19} MODIFICATION: cysteine residue {X+34} cysteine residue {X+29} MODIFICATION: cysteine residue {X+16} cysteine residue {X+34} MODIFICATION: cysteine residue {X+19} cysteine-rich region {growth arrest & DNA-damage-inducible protein GADD45 gamma COMPARTMENT: cell nucleus MOTIF: binding site FOR-BINDING-OF: proliferating cell nuclear antigen} MOTIF: cysteine residue {X+0} MODIFICATION: cysteine residue {X+14} cysteine residue {X+14} MODIFICATION: cysteine residue {X+0} cysteine residue {X+16} MODIFICATION: cysteine residue {X+29} cysteine residue {X+19} MODIFICATION: cysteine residue {X+34} cysteine residue {X+29} MODIFICATION: cysteine residue {X+16} cysteine residue {X+34} MODIFICATION: cysteine residue {X+19} transmembrane domain

Database Correlations

OMIM 153243 UniProt P28908 Pfam PF00020 Entrez Gene 943 Kegg hsa:943

References

  1. Durkop H et al, Molecular cloning and expression of a new member of the nerve growth factor receptor family that is chararteristic for Hodgkin's disease Cell 68:421-7 1992 PMID: 1310894
  2. http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
  3. Entrez Gene :accession 943
  4. UniProt :accession P28908