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K+ channel subfamily K member 9; acid-sensitive K+ channel protein TASK-3; TWIK-related acid-sensitive K+ channel 3; Two pore K+ channel KT3.2 (KCNK9 TASK3)
Function:
- pH-dependent, voltage-insensitive, background K+ channel
Structure:
- belongs to the two pore domain K+ channel (TC 1.A.1.8) family
Compartment: membrane (potential)
Expression:
- mainly found in the cerebellum
- also found in adrenal gland, kidney & lung
Pathology:
1) overexpressed in a high proportion of breast cancers
2) may confer resistance to growth factor deprivation & hypoxia, thereby promoting tumor cell survival in poorly oxygenated areas of solid tumors
3) defects in KCNK9 may be the cause of Birk Barel syndrome
Notes:
- inhibited by phorbol 12-myristate 13-acetate (PMA)
- TASK-3 current is strongly decreased in the presence of an extracellular pH inferior to 7.0
General
glycoprotein
K+ channel subfamily K
transmembrane 6 protein
Properties
SIZE: entity length = 374 aa
MW = 42 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-8}
transmembrane domain {9-29}
exoplasmic loop {30-79}
MOTIF: N-glycosylation site {N53}
transmembrane domain {80-100}
cytoplasmic loop {101-107}
transmembrane domain {108-128}
exoplasmic loop {129-158}
transmembrane domain {159-179}
cytoplasmic loop {180-185}
transmembrane domain {186-206}
exoplasmic loop {207-218}
transmembrane domain {219-239}
cytoplasmic domain {240-374}
ION-PERMEABILITY: K+
Database Correlations
OMIM 605874
UniProt Q9NPC2
Pfam PF07885
Entrez Gene 51305
Kegg hsa:51305
References
- UniProt :accession Q9NPC2
- OMIM :accession Q9NPC2