full=voltage-gated K+ channel subunit beta-1; K+ channel subunit beta-1; Kv-beta-1 (KCNAB1, KCNA1B)

Function: - accessory K⁺ channel protein which modulates activity of the pore-forming alpha subunit - all three isoforms alter the functional properties of Kv1.4 & Kv1.5 - isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1 - forms heteromultimeric complex with alpha subunits interacts with SQSTM1 (putative) Structure: - alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit (probable) - belongs to the shaker K⁺ channel beta subunit family Compartment: cytoplasm (putative) Alternative splicing: named isoforms=3 Expression: - in brain, expressed in caudate nucleus, hippocampus & thalamus > amygdala & subthalamic nucleus - expressed in both healthy & cardiomyopathic heart; up to four times more abundant in left ventricle than left atrium

Properties

SIZE: entity length = 419 aa MW = 47 kD COMPARTMENT: cytoplasm MOTIF: phosphorylation site

Database Correlations

OMIM 601141 UniProt Q14722 Pfam PF00248 Entrez Gene 7881 Kegg hsa:7881

References

UniProt :accession Q14722