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Kashin-Beck disease
Etiology:
- selenium deficiency likely risk factor
Epidemiology:
- usually involves children age 5-15 years
- highest incidence in China
Pathology:
- death of cartilage cells in the growth plate & articular surfaces
Clinical manifestations:
- joint pain
- morning stiffness in the joints
- flexion & extension disorder in the elbows
- enlarged interphalangeal joints
- ankylosis
- growth retardation
Management:
- physical therapy
- surgery
- prevention
- selenium supplementation in edemic areas
- correct iodine deficiency before selenium deficiency
General
osteochondropathy (disorder of bone & cartilage)
References
- Wikipedia: Kashin-Beck disease
http://en.wikipedia.org/wiki/Kashin-Beck_disease