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kappa opioid receptor; KOR-1 (OPRK1 OPRK)
Function:
- receptor for dynorphins
- inhibits neurotransmitter release by reducing Ca+2 currents & increasing K+ conductance
- may play a role in arousal & regulation of autonomic & neuroendocrine functions
- implication of dynorphins in LTP suggests OPRK1 may be involved as well
- interacts with SLC9A3R1
- interacts with GABARAPL1
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
General
endorphin receptor or opioid receptor
glycoprotein
Properties
SIZE: entity length = 380 aa
MW = 43 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-58}
MOTIF: N-glycosylation site {N25}
N-glycosylation site {N39}
transmembrane domain {59-85}
cytoplasmic loop {86-95}
transmembrane domain {96-117}
exoplasmic loop {118-132}
MOTIF: cysteine residue {C131}
MODIFICATION: cysteine residue {C210}
transmembrane domain {133-154}
cytoplasmic loop {155-173}
transmembrane domain {174-196}
exoplasmic loop {197-222}
MOTIF: cysteine residue {C210}
MODIFICATION: cysteine residue {C131}
transmembrane domain {223-247}
cytoplasmic loop {248-275}
transmembrane domain {276-299}
exoplasmic loop {300-311}
transmembrane domain {312-333}
cytoplasmic domain {334-380}
MOTIF: cysteine residue {C345}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 165196
UniProt P41145
Pfam PF00001
Kegg hsa:4986
References
- UniProt :accession P41145
- Wikipedia; Note: Kappa opioid receptor entry
http://en.wikipedia.org/wiki/Kappa_opioid_receptor
- Weisskopf MG, Zalutsky RA, Nicoll RA.
The opioid peptide dynorphin mediates heterosynaptic depression
of hippocampal mossy fibre synapses and modulates long-term
potentiation.
Nature. 1993 Apr 1;362(6419):423-7.
PMID: 8096624
- Reisine T, Bell GI.
Molecular biology of opioid receptors.
Trends Neurosci. 1993 Dec;16(12):506-10. Review.
PMID: 7509520