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kallikrein-7; hK7; serine protease 6; stratum corneum chymotryptic enzyme; hSCCE (KLK7, PRSS6, SCCE)
Function:
- may catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface
- specific for amino acid residues with aromatic side chains in the P1 position
- cleaves insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' & '26-Tyr-|-Thr-27'
- could play a role in the activation of precursors to inflammatory cytokines
Inhibition:
- inhibited by Zn2+ & Cu2+ at low micromolar concentrations
Structure:
- belongs to the peptidase S1 family, kallikrein subfamily
- contains 1 peptidase S1 domain
Compartment:
- secreted
- in ovarian carcinoma, secreted & also observed at the apical membrane & in cytoplasm at the invasive front
Alternative splicing: named isoforms=2
Expression:
- abundantly expressed in the skin & is expressed by keratinocytes in the epidermis
- also expressed in the brain, mammary gland, cerebellum, spinal cord & kidney
- lower expression in salivary glands, uterus, thymus, thyroid, placenta, trachea & testis
- induced by estrogens & glucocorticoids in a breast carcinoma cell line
Pathology:
- up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries & benign adenomas (at protein level)
General
glycoprotein
kallikrein
Properties
SIZE: entity length = 253 aa
MW = 28 kD
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-22}
S1 domain {30-250}
MOTIF: cysteine residue {C36}
MODIFICATION: cysteine residue {C165}
cysteine residue {C55}
MODIFICATION: cysteine residue {C71}
histidine residue {H70}
cysteine residue {C71}
MODIFICATION: cysteine residue {C55}
histidine residue {109}
aspartate residue {D112}
cysteine residue {C137}
MODIFICATION: cysteine residue {C239}
cysteine residue {C144}
MODIFICATION: cysteine residue {C211}
cysteine residue {C165}
MODIFICATION: cysteine residue {C36}
cysteine residue {C176}
MODIFICATION: cysteine residue {C190}
cysteine residue {C190}
MODIFICATION: cysteine residue {C176}
cysteine residue {C201}
MODIFICATION: cysteine residue {C226}
serine residue {S205}
cysteine residue {C211}
MODIFICATION: cysteine residue {C144}
cysteine residue {C226}
MODIFICATION: cysteine residue {C201}
cysteine residue {C239}
MODIFICATION: cysteine residue {C137}
N-glycosylation site {N246}
Database Correlations
OMIM 604438
UniProt P49862
Pfam PF00089
Entrez Gene 5650
Kegg hsa:5650
ENZYME 3.4.21.117
References
- UniProt :accession P49862
- Entrez Gene :accession 5650