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glutamate receptor, ionotropic kainate 3; glutamate receptor 7; GluR-7; GluR7; excitatory amino acid receptor 5; EAA5 (GRIK3, GLUR7)
Function:
- postsynaptic receptor for excitatory neurotransmitter L-glutamate in the central nervous system
- receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA
- interacts with PRKCABP
Structure:
- homomeric
- can also coassemble with either GRIK4 or GRIK5 to form heteromeric receptors
- belongs to the glutamate-gated ion channel (TC 1.A.10) family
Compartment:
- cell membrane
- cell junction, synapse, postsynaptic cell membrane
Genetics:
- RNA editing:
- modified positions=352, partially edited
General
glutamate receptor beta
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 919 aa
MW = 104 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-563}
MOTIF: signal sequence {1-31}
N-glycosylation site {N70}
N-glycosylation site {N76}
N-glycosylation site {N278}
N-glycosylation site {N381}
N-glycosylation site {N415}
N-glycosylation site {N426}
N-glycosylation site {N433}
Tyr phosphorylation site {Y544}
N-glycosylation site {N548}
transmembrane domain {564-584}
cytoplasmic loop {585-636}
transmembrane domain {637-657}
exoplasmic loop {658-820}
transmembrane domain {821-841}
cytoplasmic domain {842-919}
Database Correlations
OMIM 138243
UniProt Q13003
PFAM correlations
Entrez Gene 2899
References
UniProt :accession Q13003