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juvenile myelomonocytic leukemia
Epidemiology:
- children
- ~30% of childhood cases of myelodysplastic syndrome & 2% of leukemia
Pathology:
- leukocytosis with tissue infiltration
Genetics:
- associated with germline mutations in neurofibromin gene
- other implicated genes KRAS, NRAS, PTPN11
Laboratory:
- leukocytosis
- in vitro hypersensitivity of myeloid progenitors to granulocyte-macrophage colony stimulating factor (GM-CSF)
General
AML-M4; acute myelomonocytic leukemia
Database Correlations
OMIM 607785
References
OMIM :accession 607785