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jun-D proto-oncogene protein (JUND)
Function:
- binds an AP-1 site & upon cotransfection
- stimulates activity of a promoter that bears an AP-1 site
- binds DNA as a dimer (putative)
Structure:
- belongs to the bZIP family, Jun subfamily
- contains 1 bZIP domain
Compartment: nucleus
Related
junD proto-oncogene
General
jun protein family
phosphoprotein
Properties
SIZE: entity length = 347 aa
MW = 35 kD
COMPARTMENT: cell nucleus
MOTIF: alanine-rich region {158-166}
MOTIF: alanine residue (SEVERAL)
Ser phosphorylation site {S255}
Ser phosphorylation site {S259}
DNA-binding motif
SITE: 273-292
leucine zipper
SITE: 296-324
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 165162
UniProt P17535
PFAM correlations
Entrez Gene 3727
References
- Chiu R et al
Jun-B differs in its biological properties from, and is a
negative regulator of, c-Jun.
Cell 59:979 1989
PMID: 2513128
- Herschman HR
Extracellular signals, transcriptional responses and cellular
specificity
TIBS 14:455 1989
PMID: 2696174
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/JUNDID179.html