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jun-B proto-oncogene protein (JUNB)
Function:
- transcription factor
- role in regulating gene activity following the primary growth factor response
- binds to the DNA sequence 5'-TGA[CG]TCA-3'
- binds DNA as an homodimer or as an heterodimer with another member of the jun/fos family
Structure:
- belongs to the bZIP family, Jun subfamily
- contains 1 bZIP domain
Compartment: nucleus
Expression: induced by growth factors
Pathology:
- gene deletion or mutations of junB interfering with junB protein function may be associated with psoriasis & psoriatic arthritis [2]
Related
junB proto-oncogene
General
jun protein family
phosphoprotein
Properties
SIZE: entity length = 347 aa
MW = 36 kD
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T255}
Ser phosphorylation site {S259}
DNA-binding motif
SITE: 273-292
leucine zipper
SITE: 296-324
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 165161
UniProt P17275
PFAM correlations
Entrez Gene 3726
Kegg hsa:3726
References
- Chiu R et al
Jun-B differs in its biological properties from, and is a
negative regulator of, c-Jun.
Cell 59:979 1989
PMID: 2513128
- Zenz R et al.
Psoriasis-like skin disease and arthritis caused by inducible
epidermal deletion of Jun proteins.
Nature 2005 Sep 15; 437:369-75.
PMID: 16163348
- Herschman HR
Extracellular signals, transcriptional responses and cellular
specificity
TIBS 14:455 1989
PMID: 2696174
- Atlas of genetics & cytogenetics in oncology& haematology
http://atlasgeneticsoncology.org/genes/JUNBID178.html
- UniProt :accession P17275
Component-of
jun/junB complex