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JC virus
Supercoiled virus.
The virus is so named (JC virus) because it was isolated from the post mortem brain of a patient John Cunningham (JC), with PML.
Epidemiology: -JC virus is an opportunistic infection. Infection is common; antibodies to JC virus are present in 80% of adults.
Pathology:
- etiologic agent of progressive multifocal leukoencephalopathy (PML)
- JC virus causes tumors in hamsters.
- JC virus contains large T-antigen & 4 other genes
Laboratory:
- see ARUP consult [3]
Related
JC virus antibody
JC virus DNA
polyomavirus large T antigen
progressive multifocal leukoencephalopathy (PML)
General
polyomavirus
Properties
KINGDOM: virus
GENOME-TYPE: deoxyribonucleic acid (DNA)
DOUBLE-STRANDED
GENOME-SIZE: 5-9 kB
ENVELOPE: NONE
CAPSID-SYMMETRY: ICOSAHEDRAL
References
- Medical Knowledge Self Assessment Program (MKSAP) 11, 18.
American College of Physicians, Philadelphia 1998, 2018.
- Greenfield's Neuropathology, 5th ed., 1992 p. 336, 367-70
- ARUP Consult: JC Virus - PML
The Physician's Guide to Laboratory Test Selection & Interpretation
https://www.arupconsult.com/content/jc-virus