Japanese encephalitis virus

Epidemiology: - endemic in most of Asia & parts of western Pacific - infection follows bite of Colex mosquitoes Clinical manifestations: - rarely symptomatic - presentation with non-specific fever with headache - neurologic symptoms may develop rapidly - encephalitis most common - focal neurologic signs - paresis - cranial nerve palsy - flaccid paralysis - parkinsonism - coma - may present as mild, febrile aseptic meningitis Laboratory: - Japanese encephalitis virus serology - Japanese encephalitis virus IgM in CSF (early) [1] - Japanese encephalitis virus IgM in serum (later) [1] - Japanese encephalitis virus antigen - Japanese encephalitis virus RNA Radiology: - MRI of brain - thalamic lesions Management: - Japanese encephalitis virus vaccine

General

encephalitis virus flaviviridae

Properties

KINGDOM: virus GENOME-TYPE: RNA SINGLE-STRANDED NEGATIVE-STRAND GENOME-SIZE: 10 kB ENVELOPE: PRESENT CAPSID-SYMMETRY: ICOSAHEDRAL