CD103 (integrin alpha-E, mucosal lymphocyte-1 antigen, HML-1 antigen, human mucosal lymphocyte antigen 1 antigen, ITGAE)

Function: - associates with integrin beta-7 (integrin alpha-E/beta-7) Structure: - composed of an heavy & a light chains linked by a disulfide bond - the integrin I-domain (insert) is a VWFA domain - integrins with I-domains do not undergo protease cleavage - belongs to the integrin alpha chain family - contains 5 FG-GAP repeats - contains 1 VWFA domain Compartment: membrane Expression: - expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells Pathology: - hairy cell leukemia - AML - enteropathy-associated T cell lymphomas - adult HTLV-1 associated T cell leukemia

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein integrin-alpha

Properties

SIZE: entity length = 1179 aa MW = 130 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-18} N-glycosylation site {N49} cysteine residue {C70} MODIFICATION: cysteine residue {C79} cysteine residue {C79} MODIFICATION: cysteine residue {C70} cysteine residue {C126} MODIFICATION: cysteine residue {C159} X-domain (extra domain) {145-199} MOTIF: cysteine residue {C159} MODIFICATION: cysteine residue {C126} glutamate-rich region {181-198} MOTIF: glutamate residue (SEVERAL) VWFA domain {200-391} MOTIF: N-glycosylation site {N271} N-glycosylation site {N321} FG-GAP {401-456} MOTIF: N-glycosylation site {N444} FG-GAP {457-506} FG-GAP {510-571} MOTIF: Ca+2-binding site SITE: 522-530 FG-GAP {573-638} MOTIF: Ca+2-binding site SITE: 586-594 FG-GAP {641-693} MOTIF: Ca+2-binding site SITE: 654-662 cysteine residue {C706} MODIFICATION: cysteine residue {C762} N-glycosylation site {N726} cysteine residue {C762} MODIFICATION: cysteine residue {C706} N-glycosylation site {N782} cysteine residue {C823} MODIFICATION: cysteine residue {C829} cysteine residue {C829} MODIFICATION: cysteine residue {C823} N-glycosylation site {N857} cysteine residue {C893} MODIFICATION: cysteine residue {C907} cysteine residue {C907} MODIFICATION: cysteine residue {C893} N-glycosylation site {N934} N-glycosylation site {N954} cysteine residue {C1008} MODIFICATION: cysteine residue {C1033} cysteine residue {C1033} MODIFICATION: cysteine residue {C1008} cysteine residue {C1041} MODIFICATION: cysteine residue {C1057} cysteine residue {C1057} MODIFICATION: cysteine residue {C1041} N-glycosylation site {N1065} N-glycosylation site {N1096} transmembrane domain {1125-1147} GFFKR {1150-1154}

Database Correlations

OMIM 604682 UniProt P38570 PFAM correlations Entrez Gene 3682 Kegg hsa:3682