CD49e (integrin alpha-5, integrin alpha-F, fibronection receptor alpha subunit, ITGA5)

Function: - associaties with integrin beta-1 (integrin alpha-5/beta-1) - interacts with HPS5 Structure: - composed of an heavy & a light chain linked by a disulfide bond - belongs to the integrin alpha chain family - contains 7 FG-GAP repeats Compartment: membrane Pathology: - interacts with HIV-1 Tat (see VLA-5)

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen integrin-alpha

Properties

SIZE: entity length = 1049 aa MW = 115 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-41} FG-GAP {57-119} MOTIF: N-glycosylation site {N84} cysteine residue {C99} MODIFICATION: cysteine residue {C108} cysteine residue {C108} MODIFICATION: cysteine residue {C99} FG-GAP {131-198} MOTIF: cysteine residue {C156} MODIFICATION: cysteine residue {C176} cysteine residue {C176} MODIFICATION: cysteine residue {C156} N-glycosylation site {N182} cysteine residue {C192} MODIFICATION: cysteine residue {C205} FG-GAP {199-256} MOTIF: cysteine residue {C205} MODIFICATION: cysteine residue {C192} FG-GAP {269-322} MOTIF: N-glycosylation site {N297} N-glycosylation site {N307} N-glycosylation site {N316} FG-GAP {323-389} MOTIF: Ca+2-binding site SITE: 334-342 FG-GAP {390-449} MOTIF: Ca+2-binding site SITE: 401-409 FG-GAP {453-505} MOTIF: Ca+2-binding site SITE: 465-473 cysteine residue {C513} MODIFICATION: cysteine residue {C522} cysteine residue {C522} MODIFICATION: cysteine residue {C513} N-glycosylation site {N524} cysteine residue {C528} MODIFICATION: cysteine residue {C584} N-glycosylation site {N530} cysteine residue {C584} MODIFICATION: cysteine residue {C528} N-glycosylation site {N593} N-glycosylation site {N609} cysteine residue {C645} MODIFICATION: cysteine residue {C651} cysteine residue {C651} MODIFICATION: cysteine residue {C645} N-glycosylation site {N675} N-glycosylation site {N712} cysteine residue {C718} MODIFICATION: cysteine residue {C731} N-glycosylation site {N724} cysteine residue {C731} MODIFICATION: cysteine residue {C718} N-glycosylation site {N773} N-glycosylation site {N868} cysteine residue {C869} MODIFICATION: cysteine residue {C-INTERCHAIN} cysteine residue {C911} MODIFICATION: cysteine residue {C916} cysteine residue {C916} MODIFICATION: cysteine residue {C911} transmembrane domain {996-1021} HPS5 interaction {1021-1028} MOTIF: GFFKR {1024-1028}

Database Correlations

OMIM 135620 UniProt P08648 PFAM correlations Entrez Gene 3678 Kegg hsa:3678