Contents

Search

CD49d (integrin alpha-4, VLA-4 alpha chain, ITGA4)

Function: - associates with integrin beta-1 (integrin alpha-4/beta-1) & integrin beta-7 (integrin alpha-4/beta-7) - can sometimes be cleaved into two non-covalently associated fragments - interacts with PXN, LPXN, & TGFB1I1/HIC5 - interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan - phosphorylation on Ser-1027 inhibits PXN binding - mportant for generation of neurites & in neuronal plasticity [2] Structure: - the SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan & cell adhesion - belongs to the integrin alpha chain family - contains 7 FG-GAP repeats Compartment: membrane

General

Ca+2 binding protein cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein integrin-alpha

Properties

SIZE: entity length = 1038 aa MW = 115 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-39} FG-GAP {55-117} MOTIF: N-glycosylation site {N85} cysteine residue {C97} MODIFICATION: cysteine residue {C107} cysteine residue {C107} MODIFICATION: cysteine residue {C97} FG-GAP {118-193} MOTIF: N-glycosylation site {N144} cysteine residue {C150} MODIFICATION: cysteine residue {C171} cysteine residue {C171} MODIFICATION: cysteine residue {C150} cysteine residue {C189} MODIFICATION: cysteine residue {C204} FG-GAP {194-253} MOTIF: cysteine residue {C204} MODIFICATION: cysteine residue {C189} N-glycosylation site {N235} FG-GAP {254-306} FG-GAP {309-368} MOTIF: Ca+2-binding site SITE: 320-328 FG-GAP {371-430} MOTIF: Ca+2-binding site SITE: 383-391 FG-GAP {433-485} MOTIF: Ca+2-binding site SITE: 445-453 N-glycosylation site {N486} cysteine residue {C492} MODIFICATION: cysteine residue {C501} cysteine residue {C501} MODIFICATION: cysteine residue {C492} cysteine residue {C507} MODIFICATION: cysteine residue {C563} N-glycosylation site {N524} N-glycosylation site {N544} cysteine residue {C563} MODIFICATION: cysteine residue {C507} peptide motif {597-598} cysteine residue {C628} MODIFICATION: cysteine residue {C633} N-glycosylation site {N632} cysteine residue {C633} MODIFICATION: cysteine residue {C628} N-glycosylation site {N651} N-glycosylation site {N666} cysteine residue {C704} MODIFICATION: cysteine residue {C717} cysteine residue {C717} MODIFICATION: cysteine residue {C704} N-glycosylation site {N812} N-glycosylation site {N827} cysteine residue {C858} MODIFICATION: cysteine residue {C896} cysteine residue {C896} MODIFICATION: cysteine residue {C858} cysteine residue {C903} MODIFICATION: cysteine residue {C908} cysteine residue {C908} MODIFICATION: cysteine residue {C903} transmembrane domain {984-1007} GFFKR {1009-1013} Ser phosphorylation site {S1027}

Database Correlations

OMIM 192975 UniProt P13612 PFAM correlations Entrez Gene 3676 Kegg hsa:3676

References

  1. Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 921
  2. Rampon C, Jiang CH, Dong H, Tang YP, Lockhart DJ, Schultz PG, Tsien JZ, Hu Y. Effects of environmental enrichment on gene expression in the brain. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12880-4. PMID: 11070096
  3. Entrez Gene :accession 3676
  4. UniProt :accession P13612

Component-of

integrin alpha-4/beta-7