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isradipine (DynaCirc)
Tradename: DynaCirc.
Dosage: start 2.5 mg PO BID, max 20 mg QD.
Tabs: 2.5, 5 mg.
Pharmacokinetics:
-> metabolized in the liver by cyt P450 3A4
Drug interactions:
1) any drug that inhibits cyt P450 3A4 may increase levels of isradipine
2) any drug that induces cyt P450 3A4 may diminish levels of isradipine
Interactions
drug interactions
drug adverse effects (more general classes)
Related
cytochrome P450 3A4 (cytochrome P450 C3, nifedipine oxidase, P450-PCN1, NF-25, CYP3A4)
General
calcium channel blocker (CCB)
dihydropyridine
Properties
MISC-INFO: elimination route LIVER
pregnancy-category C
safety in lactation ?
Database Correlations
PUBCHEM cid=3784
References
The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996