isotype switching (GO:0045190)

The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. Notes: - Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'.

Specific

isotype switching to IgA isotypes (GO:0048290) isotype switching to IgD isotypes (GO:0048292) isotype switching to IgE isotypes (GO:0048289) isotype switching to IgG isotypes (GO:0048291)

General

single-organism metabolic process (GO:0044710) B cell activation involved in immune response (GO:0002312) somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)

References

gene ontology: GO:0045190