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isosorbide mononitrate (ISMO, Monoket, Imdur)
Tradenames: ISMO, Monoket. Alias ISMN.
Indications:
- angina pectoris
- prophylaxis for angina pectoris
- chronic heart failure
Dosage: 20 mg PO every 7 hours. 2 doses/day Tabs: 10 & 20 mg. Extended-release: Tradename: Imdur. 30-240 mg PO QD. Tabs: 60 mg.
* An 8-12 hour nitrate-free period needed to avoid nitrate tolerance [2]
Adverse effects:
- may adversely affect (diminish) activity levels in patients with LV diastolic dysfunction [3]
Notes:
- mononitrates are less prone than dinitrates to cause tolerance
Interactions
drug interactions
drug adverse effects of antihypertensive agents
General
nitrate
Properties
MISC-INFO: elimination route LIVER
pregnancy-category C
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Medical Knowledge Self Assessment Program (MKSAP) 11, 19.
American College of Physicians, Philadelphia 1998, 2022
- Redfield MM, Anstrom KJ, Levine JA et al
Isosorbide Mononitrate in Heart Failure with Preserved
Ejection Fraction.
N Engl J Med. November 8, 2015
PMID: 26549714
http://www.nejm.org/doi/full/10.1056/NEJMoa1510774
Component-of
cilostazol/isosorbide mononitrate