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ISGylation

Conjugation of a target protein with ubiquitin-like protein ISG15. Substrates for ISGylation by ISG15 include: 1) serpin 2A 2) phospholipase C-gamma 1 3) JAK1 4) ERK1 5) STAT1 6) DDX58 (after IFN-beta stimulation) , ISGylation may play a role in: -> JAK-STAT pathway

Related

interferon-induced 17 kD protein; contains: ubiquitin cross-reactive protein; hUCRP; interferon-induced 15 kD protein (IFP17, ISG15, G1P2, UCRP)

General

protein conjugation

References

  1. Hemelaar J, Borodovsky A, Kessler BM, Reverter D et al Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol. 2004 Jan;24(1):84-95. PMID: 14673145
  2. UniProt :accession O95786