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ischemia-modified albumin in serum/plasma
Indications:
- assessement of acute myocardial infarction (MI) measured within 24 hours of acute MI
- assessment of myocardial perfusion during coronary bypass surgery
Procedure:
- albumin cobalt binding assay
Clinical significance:
- predicts poor cardiac outcome at 1 year after MI
- reveals myocardial perfusion defect during coronary bypass surgery [2]
- helpful in establishing diagnosis in the early stages of ischemia, before necrosis develops [2]
Notes:
- never widely used and is no longer available for clinical use in the U.S. [3]
General
albumin in serum/plasma
References
- Van Belle E et al
Ischemia-modified albumin levels predict long-term outcome in
patients with acute myocardial infarction. The French Nationwide
OPERA study.
Am Heart J. 2010 Apr;159(4):570-6.
PMID: 2036271
- Kanko M et al
Ischemia-modified albumin use as a prognostic factor in
coronary bypass surgery
Journal of Cardiothoracic Surgery 2012, 7:3
http://www.cardiothoracicsurgery.org/content/7/1/3
- Lab Tests Online: IMA
http://labtestsonline.org/understanding/analytes/ima/tab/test