iroquois-class homeodomain protein IRX-5; homeodomain protein IRX-2A; homeodomain protein IRXB2; iroquois homeobox protein 5 (IRX5, IRX2A, IRXB2)

Function: - establishes the cardiac repolarization gradient by its repressive actions on the KCND2 K⁺-channel gene - required for retinal cone bipolar cell differentiation - may regulate contrast adaptation in the retina & control specific aspects of visual function in circuits of the mammalian retina Structure: - belongs to the TALE/IRO homeobox family - contains 1 homeobox DNA-binding domain Compartment: nucleus (probable) Pathology: - could be involved in the regulation of both the cell cycle & apoptosis in prostate cancer cells - down-regulated by 1,25-dihydroxyvitamin D3 in prostate cancer samples from patients assigned to receive weekly high-dose 1,25-dihydroxyvitamin D3 before radical prostatectomy - also down- regulated by 1,25-dihydroxyvitamin D3 in the human androgen-sensitive prostate cancer cell line LNCaP & in the estrogen-sensitive breast cancer cell line MCF-7

Properties

SIZE: entity length = 483 aa MW = 50 kD COMPARTMENT: cell nucleus MOTIF: alanine-rich region {72-78} MOTIF: alanine residue (SEVERAL) homeodomain SITE: 113-175 glutamate-rich region {186-192} MOTIF: glutamate residue (SEVERAL) proline-rich region SITE: 320-326 MOTIF: proline residue (SEVERAL) glycine-rich region {350-353}

Database Correlations

OMIM 606195 UniProt P78411 Pfam PF00046 Entrez Gene 10265 Kegg hsa:10265

References

UniProt :accession P78411