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iroquois-class homeodomain protein IRX-3; homeodomain protein IRXB1; iroquois homeobox protein 3 (IRX3, IRXB1)
Function:
- transcription factor
- involved in SHH-dependent neural patterning
- together with NKX2-2 & NKX6-1, acts to restrict the generation of motor neurons to the appropriate region of the neural tube
- belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals
- involved in the transcriptional repression of MNX1 in non-motor neuron cells (putative)
Structure:
- belongs to the TALE/IRO homeobox family
- contains 1 homeobox DNA-binding domain
Compartment: nucleus (probable)
General
Iroquois-class homeodomain protein IRX
Properties
SIZE: entity length = 501 aa
MW = 52 kD
COMPARTMENT: cell nucleus
MOTIF: alanine-rich region {62-70}
MOTIF: alanine residue (SEVERAL)
homeodomain
SITE: 125-188
acidic region {201-267}
MOTIF: acidic residue (SEVERAL)
glutamate-rich region {229-232}
MOTIF: glutamate residue (SEVERAL)
proline-rich region
SITE: 304-433
MOTIF: proline residue (SEVERAL)
alanine-rich region {388-394}
MOTIF: alanine residue (SEVERAL)
alanine-rich region {446-450}
MOTIF: alanine residue (SEVERAL)
Database Correlations
OMIM 612985
UniProt P78415
Pfam PF00046
Entrez Gene 79191
Kegg hsa:79191
References
UniProt :accession P78415