interferon regulatory factor 7 (IRF7)

Function: - transcriptional activator - binds to the interferon-stimulated response element (ISRE) in IFN promoters & in the Q promoter of EBV nuclear antigen 1 (EBNA1) - functions as a molecular switch for antiviral activity - activated by phosphorylation in response to infection - activation leads to nuclear retention, DNA binding, & derepression of transactivation ability - in response to a viral infection, phosphorylated on the C-terminal Ser cluster - phosphorylation, & subsequent activation is inhibited by vaccinia virus protein E3 - interacts with TICAM1 & TICAM2 Structure: - homodimer; phosphorylation-induced - belongs to the IRF family - contains 1 tryptophan pentad repeat DNA-binding domain Compartment: - nucleus, cytoplasm - phosphorylated & active form accumulates selectively in nucleus Alternative splicing: - named isoforms=4 - one or more isoforms may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay Expression: - expressed predominantly in spleen, thymus & peripheral blood leukocytes - induced by type 1 interferons

General

interferon regulatory factor family phosphoprotein

Properties

SIZE: entity length = 503 aa MW = 54 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: DNA-binding motif SITE: 13-122 Ser phosphorylation site {S471} Ser phosphorylation site {S472} Ser phosphorylation site {S483} Ser phosphorylation site {S484}

Database Correlations

OMIM 605047 UniProt Q92985 Pfam PF00605 Entrez Gene 3665 Kegg hsa:3665