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interferon regulatory factor 1 (IRF1)
Function:
- specifically binds to the upstream regulatory region of type 1 IFN & IFN-inducible MHC class 1 genes (the interferon consensus sequence, ICS) & activates those genes
Structure:
- belongs to the IRF family
- contains 1 tryptophan pentad repeat DNA-binding domain
Compartment: nucleus
Expression: induced by viruses & IFN
Pathology:
- deletion or rearrangement of IRF1 are a cause of preleukemic myelodysplastic syndrome (MDS) & of acute myelogenous leukemia (AML)
General
interferon regulatory factor family
Properties
SIZE: MW = 37 kD
entity length = 325 aa
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 7-109
Database Correlations
OMIM correlations
UniProt P10914
Pfam PF00605
Entrez Gene 3659
KEGG correlations
References
- UniProt :accession P10914
- Entrez Gene :accession 3659