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iron response element

stem-loop structures found in: - 5' untranslated region of ferritin mRNA - 5' untranslated region of delta amino-levulinate mRNA - 3' untranslated region of transferrin receptor mRNA - cytoplasmic-membrane overlapping region of APP mRNA (putative) Function: - presumably inhibitory motif - binding of IREB1 to the IRE element in ferritin mRNA results in repression of its translation - binding of IREB1 to the transferrin receptor mRNA inhibits otherwise rapid degradation

Related

iron-responsive element [IRE]-binding protein

General

transcription factor binding site

References

  1. Hentze et al Science 244:357 1989
  2. Klausner and Harford Science 246:870 1990
  3. UniProt :accession P21399