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interleukin-1 receptor associated kinase 4 (IRAK4, NY-REN-64 antigen)
Function:
1) recruitment of IRAK1 to the IL-1 receptor complex
2) phosphorylates IRAK1
3) interacts with IL1RL1
Cofactor: Mg+2
Structure:
- belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily
- contains 1 death domain
- contains 1 protein kinase domain
Pathology:
- defects in IRAK4 are the cause of
a) recurrent invasive pneumococcal disease type 1
b) IRAK4 deficiency
General
interleukin-1 receptor associated kinase (IRAK)
Properties
SIZE: entity length = 460 aa
MW = 52 kD
STATE: active state
MOTIF: death domain
NAME: death domain
SITE: 20-104
Ser phosphorylation site {S152}
kinase domain
SITE: 186-454
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 192-200
ATP-binding site
NAME: ATP-binding site
SITE: 213-213
aspartate residue {D311}
Database Correlations
OMIM correlations
MORBIDMAP 606883
UniProt Q9NWZ3
Pfam PF00069
Entrez Gene 51135
Kegg hsa:51135
ENZYME 2.7.1.37
References
- UniProt :accession Q9NWZ3
- IRAK4base; Note: IRAK4 mutation db
http://bioinf.uta.fi/IRAK4base/
- SeattleSNPs
http://pga.gs.washington.edu/data/irak4/