desirudin (Iprivask)

Indications: - prophylaxis for deep vein thrombosis with elective hip replacement Dosage: - 15 mg SC every 12 hours Injection: lyophilized powder 15 mg Pharmacokinetics: - metabolized & eliminated by the kidney - 40-50% excreted unchanged - 1/2life ~ 2 hours Elimination Mean terminal elimination t is approximately 2 h. Adverse effects: - black box warning Laboratory: - aPTT is a measure of the anticoagulant activity of desirudin Mechanism of action: - thrombin inhibitor

References

- Drugs.com http://www.drugs.com/ppa/desirudin.html