ionized Ca+2 in serum/plasma

Reference values: - plasma (heparin) - adults: 4.12-4.92 mg/dL (1.03-1.23 nmol/L) Clinical significance: - determines free or biologically active Ca⁺², thus determines 'true' hypercalcemia or 'true' hypocalcemia Increases: 1) clinical disorders a) decreased plasma pH (acidemia) b) primary hyperparathyroidism c) PTH producing tumors (hypercalcemia of malignancy) d) excess intake of vitamin D 2) pharmaceutical agents -> in vivo effects -> hydrochlorothiazide (chronic use), lithium Decreases: 1) clinical disorders a) increased plasma pH (alkalemia) b) increased plasma ionic strength c) primary hypoparathyroidism d) pseudohypoparathyroidism e) vitamin D deficiency f) magnesium deficiency g) major surgery h) trauma i) sepsis j) burns k) pancreatitis l) multiple organ failure m) hemodialysis with low calcium diasylate 2) pharmaceutical agents a) in vivo effects -> anticonvulsants, danazol, foscarnet, furosemide (initial effect), transfusion with citrate- containing products b) chemical interferences -> Ca⁺²-binding agents (EDTA, citrate, oxalate, heparin) Method: ion-specific electrode Specimen: 1) whole blood or plasma (heparin) 2) collect blood anaerobically 3) place on ice & deliver to lab immediately 4) plasma or serum may be stored in a tightly sealed container at 4 degrees C for several days or at -20 degrees C for 6 months

General

ionized Ca+2 in serum/plasma/blood

References

Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
Mini Panel of 2 tests: Calcium, Ionized Serum . Calcium Ionized pH 7.4 Laboratory Test Directory ARUP: 20135

Component-of

chemistry 8 panel with ionized calcium; basic metabolic panel (BMP) with ionized calcium coma panel pancreatic panel parathyroid panel

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