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allograft inflammatory factor 1; AIF-1; ionized Ca+2-binding adapter molecule 1; protein G1 (AIF1, G1, IBA1)
Function:
- actin-binding protein
- enhances membrane ruffling & RAC activation
- enhances the actin-bundling activity of LCP1
- binds Ca+2
- role in RAC signaling & in phagocytosis
- may play a role in macrophage activation & function
- promotes proliferation of vascular smooth muscle cells & of T-cells
- enhances lymphocyte migration
- role in vascular inflammation
- phosphorylated on Ser
- homodimer (putative). monomer
- interacts with LCP1
Structure:
- contains 2 EF-hand domains
Compartment:
- cytoplasm, cytoskeleton, cell projection, membrane ruffle
- peripheral membrane, cytoplasmic side
- associated with the actin cytoskeleton at membrane ruffles & at sites of phagocytosis
Alternative splicing: named isoforms=3
Expression:
- detected in T-cells & peripheral blood mononuclear cells
General
Ca+2 binding protein
human longevity protein
phosphoprotein
Properties
SIZE: entity length = 147 aa
MW = 17 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S39}
EF hand
SITE: 45-80
MOTIF: Ca+2-binding site
SITE: 58-69
EF hand
SITE: 81-115
MOTIF: Ca+2-binding site
SITE: 94-105
Database Correlations
OMIM 601833
UniProt P55008
Entrez Gene 199
Kegg hsa:199
References
- UniProt :accession P55008
- UniProt PubMed refs
- PMID: 16049345
- PMID: 049345