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intracytoplasmic sperm injection (ICSI)

May successfully impregnate eggs harvested from female partners. Procedure: - injection of a single motile sperm (or immature spermatid) directly into an oocyte Clinical significance: - this technique has permitted men with severe sperm abnormalities, extremely low sperm counts, or both, to father children Complications: 1) 3.5% risk of abnormal karyotype in offspring 2) 2-fold risk in major birth defects [3]

Related

assisted reproduction technology (ART) infertility

General

in vitro fertilization (IVF)

References

  1. Journal Watch 21(18):146, 2001 Aboulghar et al, Fertil Steril 76:249, 2001
  2. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  3. Journal Watch 22(8):66, 2002 Lynch A etal, Obstet Gynecol 99:445, 2002