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intestinal epithelium
Function:
- absorption of substances
- providing a barrier against harmful substances
- control passage of water, various molecules, cells, & organisms from the gut lumen into the tissues & circulation
Structure:
- simple columnar epithelium
Pathology:
- hyperglycemia makes the gut barrier more permeable to bacterial products & live bacteria [3]
- genetic variants in INAVA (Clorf106) increase risk for inflammatory bowel disease
Related
intestinal bacteria (flora)
intestinal epithelial cell
General
columnar epithelium
References
- Wikipedia: Intestinal epithelium
https://en.wikipedia.org/wiki/Intestinal_epithelium
- Peterson LW, Artis D
Intestinal epithelial cells: regulators of barrier function
and immune homeostasis.
Nat Rev Immunol. 2014 Mar;14(3):141-53. Review.
PMID: 24566914
https://www.nature.com/articles/nri3608
- Mohanan V, Nakata T, Desch AN et al.
Clorf106 is a colitis risk gene that regulates stability of
epithelial adherens junctions.
Science 2018 Mar 9; 359:1161.
PMID: 29420262
- Manfredo Vieira S, Hiltensperger M, Kumar V et al.
Translocation of a gut pathobiont drives autoimmunity in mice
and humans.
Science 2018 Mar 9; 359:1156.
PMID: 29590047
- Thaiss CA, Levy M, Grosheva I et al.
Hyperglycemia drives intestinal barrier dysfunction and risk
for enteric infection.
Science 2018 Mar 23; 359:1376.
PMID: 29519916
- Citi S et al.
Intestinal barriers protect against disease.
Science 2018 Mar 9; 359:1097
PMID: 29590026