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interstitial lung abnormality
Abnormlalities incidentally identified involving at least 5% of a lung zone
- ground-glass or reticular abnormalities
- lung distortion
- traction bronchiectasis
- honeycombing
- non-emphysematous cysts
Epidemiology:
- prevalence is 7% with screening for lung cancer with low-dose CT
- prevalence is 7% with lung CT done for other reasons
Complications:
- progression to interstitial lung disease
- excess 5 year mortality (RR=1.4-8.2)
Management:
- review of medical history, especially
- respiratory symptoms
- inhaled exposures
- drugs with lung toxicity
- occult systemic diseases with pulmonary manifestations
- conditions with predisposition to recurrent infection
- recurrent aspiration pneumonitis
Related
solitary pulmonary nodule; pulmonary coin lesion
General
abnormal imaging
References
- Hatabu H et al.
Interstitial lung abnormalities detected incidentally on CT:
A position paper from the Fleischner Society.
Lancet Respir Med 2020 Jul; 8:726.
PMID: 32649920 PMCID: PMC7970441 Free PMC article
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30168-5/fulltext
- Grant-Orser A et al.
Prevalence, risk factors, and outcomes of adult interstitial lung abnormalities:
A systematic review and meta-analysis.
Am J Respir Crit Care Med 2023 Sep 15; 208:695.
PMID: 37534937 PMCID: PMC10515575 (available on 2024-09-15)
https://www.atsjournals.org/doi/10.1164/rccm.202302-0271OC
- Luo F et al.
Adult interstitial lung abnormalities: The new frontier of pulmonary fibrosis.
Am J Respir Crit Care Med 2023 Sep 15; 208:651.
PMID: 37552023 PMCID: PMC10515573 Free PMC article
https://www.atsjournals.org/doi/10.1164/rccm.202307-1287ED