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intermediate filament
Structure:
- cytoskeletal filaments:
- microtubules: 25 nm
- intermediate filaments: 10-12 nm (includes neurofilaments)
- microfilaments: 7-10 nm Distributed in both cytoplasm & nucleus.
Related
intermediate filament disorder
Specific
neurofilament
tonofilament
General
filament
Properties
SUBUNITS: intermediate filament protein
MOTIF: O-glycosylation site {N-TERMINAL}
rod-like {central-region}
MOTIF: alpha helix
coiled coil
glutamate-rich region {C-TERMINAL}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site (SEVERAL)
MOTIF-SEQUENCE: KSP
References
- Cairns NJ, Lee VM, Trojanowski JQ.
The cytoskeleton in neurodegenerative diseases.
J Pathol. 2004 Nov;204(4):438-49. Review.
PMID: 15495240
- Omary MB, Coulombe PA, McLean WH.
Intermediate filament proteins and their associated diseases.
N Engl J Med. 2004 Nov 11;351(20):2087-100. Review.
PMID: 15537907
Components
intermediate filament protein