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interleukin-8; IL-8; C-X-C motif chemokine 8; monocyte-derived neutrophil chemotactic factor; MDNCF; T-cell chemotactic factor; neutrophil-activating protein 1; NAP-1; protein 3-10C; Granulocyte chemotactic protein 1; GCP-1; monocyte-derived neutrophil-activating peptide; MONAP; emoctakin; lymphocyte-derived neutrophil-activating factor; LYNAP; neutrophil-activating factor; leukocyte adhesion inhibitor; NAF; MDNCF-c (IL8, CXCL8)

Function: - chemotactic factor that attracts neutrophils, basophils, & T-cells, but not monocytes - role in neutrophil activation - mediates transendothelial neutrophil migration - mitogenic for endothelial cells - released from several cell types in response to an inflammatory stimulus - IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation & IL-8(7-77) has a higher affinity to receptors CXCR1 & CXCR2 as compared to IL-8(1-77) - several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes & endothelial cells Structure: - homodimer - belongs to the intercrine alpha (chemokine CxC) family - in general, IL-8(1-77) is referred to as interleukin-8 - IL-8(6-77) is the most promiment form Compartment: secreted Alternative splicing: named isoforms=2 Pathology: - elevated in pancreatic exocrine secretion with pancreatitis, but does not distinguish from pancreatic cancer [6]

Interactions

molecular events

Related

interleukin 8 (IL8) in serum/plasma interleukin-8 receptor (IL8 receptor)

General

CXC chemokine; alpha chemokine interleukin monokine sis family protein

Properties

SIZE: entity length = 99 aa MW = 11 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-20} cleavage by thrombin {27-28} cleavage by MMP9 {28-29} cysteine residue {C34} MODIFICATION: cysteine residue {C61} cysteine residue {C36} MODIFICATION: cysteine residue {C77} cysteine residue {C61} MODIFICATION: cysteine residue {C34} cysteine residue {C77} MODIFICATION: cysteine residue {C36}

References

  1. Matsushima et al Cytokine 1:2 1989
  2. Koch AE et al, Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258:1798 1992 PMID: 1281554
  3. Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: 1589908
  4. Wu D et al G protein-coupled signal transduction pathways for interleukin-8. Science 261:101 1993 PMID: 8316840
  5. Entrez Gene :accession 3576
  6. Noh KW et al, Do cytokine secretions in pancreatic juice predict the presence of pancreatic disease? Clin Gastroenterol Hepatol 2006, 4:782 PMID: 16713745
  7. UniProt :accession P10145
  8. Wikipedia; interleukin-8 entry http://en.wikipedia.org/wiki/interleukin_8
  9. SeattleSNPs http://pga.gs.washington.edu/data/il8/

Databases & Figures

OMIM 146930 UniProt P10145 Pfam PF00048 Entrez Gene 3576 Kegg hsa:3576 CXC ligand and receptor binding