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interleukin-28B; IL-28B; cytokine Zcyto22; interferon lambda-3; IFN-lambda-3; interleukin-28C; IL-28C (IL28B, IFNL3, IL28C, ZCYTO22)
Function:
1) cytokine with immunomodulatory activity
2) antiviral immunity
3) up-regulates MHC class I antigen expression
4) ligand for the heterodimeric class II cytokine receptor IL10RB/IL28RA
5) signals through the Jak-STAT pathway.
Compartment: secreted
Expression: induction by viral infections or dsRNA
Pharmacology:
- IL28B variation rs12979860 predicts response to PEG-interferon-alpha
Related
interferon lambda-4; IFN-lambda-4 (IFNL4)
General
interleukin
Properties
SIZE: entity length = 196 aa
MW = 22 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
cysteine residue {C37}
MODIFICATION: cysteine residue {C136}
cysteine residue {C71}
MODIFICATION: cysteine residue {C169}
cysteine residue {C136}
MODIFICATION: cysteine residue {C37}
cysteine residue {C169}
MODIFICATION: cysteine residue {C71}
cysteine residue {C188}
MODIFICATION: cysteine residue {C195}
cysteine residue {C195}
MODIFICATION: cysteine residue {C188}
Database Correlations
OMIM 607402
UniProt Q8IZI9
Entrez Gene 282617
Kegg hsa:282617
References
- Entrez Gene :accession 282617
- UniProt :accession Q9UBU7