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interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8 (IL17A, IL-17A, CTLA-8)

Function: 1) induces stromal cells to produce proinflammatory & hematopoietic cytokines 2) enhances surface expression of the ICAM1 in fibroblasts Structure: homodimer Compartment: - secreted - found both in glycosylated & nonglycosylated forms Expression: restricted to activated memory T-cells Pathology: - appears to play a role in chronic plaque psoriasis [3]

Related

interleukin 17A in serum/plasma

General

interleukin-17 (IL-17)

Properties

SIZE: MW = 18 kD entity length = 155 aa COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-23} N-glycosylation site {N68} cysteine residue {C94} MODIFICATION: cysteine residue {C144} cysteine residue {C99} MODIFICATION: cysteine residue {C146} cysteine residue {C144} MODIFICATION: cysteine residue {C94} cysteine residue {C146} MODIFICATION: cysteine residue {C99}

Database Correlations

OMIM 603149 UniProt Q16552 Pfam PF06083 Entrez Gene 3605 Kegg hsa:3605

References

  1. Entrez Gene :accession 3605
  2. UniProt :accession Q16552
  3. Papp KA et al. Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. N Engl J Med 2012 Mar 29; 366:1181. PMID: 22455412 - Leonardi C et al. Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N Engl J Med 2012 Mar 29; 366:1190. PMID: 22455413
  4. R&D systems' cytokine mini-reviews: IL-17 http://www.rndsystems.com/molecule_detail.aspx?m=1674
  5. Wikipedia; Note: interleukin-17 entry http://en.wikipedia.org/wiki/interleukin_17
  6. SeattleSNPs http://pga.gs.washington.edu/data/il17/