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interleukin-10; IL-10; cytokine synthesis inhibitory factor; CSIF (IL10)

Function: 1) anti-inflammatory properties 2) inhibits synthesis of cytokines (IFN gamma & IL-2) by T-cells 3) inhibits Th1 cell proliferation 4) inhibits macrophage production of: a) IL-1 beta b) IL-6 c) IL-8 d) IL-12 e) TNF-alpha 5) inhibits Th2 production of: a) IL-4 b) IL-5 6) may play a role in antigen-specific tolerance a) inhibits eosinophil survival b) inhibits IL-4 induced IgE synthesis Structure: - sequence homology with EBV-encoded protein

Related

interleukin 10 (IL-10) in serum/plasma interleukin-10 receptor (IL10 receptor)

General

glycoprotein interleukin

Properties

SIZE: entity length = 178 aa MW = 21 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-18} cysteine residue {C30} MODIFICATION: cysteine residue {C126} cysteine residue {C80} MODIFICATION: cysteine residue {C132} cysteine residue {C126} MODIFICATION: cysteine residue {C30} cysteine residue {C132} MODIFICATION: cysteine residue {C80} N-glycosylation site {N134} SECRETED-BY: T helper 2 cell macrophage

Database Correlations

OMIM correlations UniProt P22301 Pfam PF00726 Entrez Gene 3586 Kegg hsa:3586

References

  1. Moore KW, Vieira P, Fiorentino DF, Trounstine ML, Khan TA, Mosmann TR. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science. 1990 Jun 8;248(4960):1230-4. Erratum in: Science 1990 Oct 26;250(4980):494. PMID: 2161559
  2. Entrez Gene :accession 3586
  3. Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: 1589908
  4. Scott P IL-12: initiation cytokine for cell-mediated immunity Science 260:496 1993 PMID: 8097337 (secretion)
  5. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  6. UniProt :accession P22301
  7. Wikipedia; Note: interleukin-10 entry http://en.wikipedia.org/wiki/interleukin_10
  8. SeattleSNPs http://pga.gs.washington.edu/data/il10/
  9. SHMPD; Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL10