interleukin-1; lymphocyte-activating factor (IL1)

Function: - involved in the inflammatory response, - endogenous pyrogen - stimulates the release of prostaglandin & collagenase from synovial cells Compartment: - secreted - the lack of a specific hydrophobic segment in the precursor suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins Expression: - secreted by monocytes, macrophages, endothelial cells, fibroblasts & keratinocytes

Related

canakinumab (Ilaris) interleukin-1 receptor (IL1R) interleukin-1 [IL-1] binding protein

Specific

interleukin-1 alpha; IL-1 alpha; hematopoietin-1 (IL1A, IL1F1) interleukin-1 beta; IL-1 beta; catabolin (IL1B, IL1F2) interleukin-1 family member interleukin-1 theta; interleukin-1 family member 10; IL-1F10; FIL1 theta; interleukin-1 HY2; IL-1HY2; IL-1 theta (IL1F10, FIL1T, IL1HY2, FKSG75, UNQ6119/PRO20041) interleukin-1-like protein 1; interleukin-36 receptor antagonist protein; FIL1 delta; IL-1-related protein 3; IL-1RP3; interleukin-1 HY1; IL-1HY1; interleukin-1 delta; IL-1 delta; interleukin-1 family member 5; IL-1F5; interleukin-1 receptor antagonist homolog 1; IL-1ra homolog 1; IL-1L1 (IL36RN, FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3, UNQ1896/PRO4342)

General

interleukin monokine secreted peptide without leader

Properties

SIZE: MW = 17.5 kD COMPARTMENT: extracellular compartment

References

- Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: 1589908