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interferon [IFN]-alpha

Function: - antiviral activities - stimulates the production of two enzymes - a protein kinase - oligoadenylate synthetase Compartment: secreted Pathology: - auto-antibodies to IFN type 1 are present in 0.18% of persons 18-69 years, 1.1% of persons 70-80 years & 3.4% of persons > 80 years [2] - auto-antibodies to IFN type 1 account for both critical cases of COVID-19 in elderly > 80 years & total COVID-19 mortality [2] Laboratory: - interferon alpha in serum/plasma - interferon alpha Ab in serum/plasma

Related

interferon [IFN] alpha/beta receptor peginterferon

Specific

interferon [IFN]-alpha 10; IFN-alpha C; IFN-alpha 6L; LEIF C (IFNA10) interferon [IFN]-alpha 14; IFN-alpha H; IFN-lambda 2H; LEIF H (IFNA14) interferon [IFN]-alpha 16; IFN-alpha WA (IFNA16) interferon [IFN]-alpha 17; IFN-alpha T; IFN-alpha I'; IFN-alpha 88 (IFNA17) interferon [IFN]-alpha 1; IFN-alpha 13; IFN-alpha D; LEIF D (IFNA1) interferon [IFN]-alpha 21; IFN-alpha F; LEIF F (IFNA21) interferon [IFN]-alpha 2; interferon [IFN]-alpha 3; IFN-alpha A; LEIF A (IFNA2) interferon [IFN]-alpha 4; IFN-alpha 4B; IFN-alpha M1; IFN-alpha 76 (IFNA4) interferon [IFN]-alpha 5; IFN-alpha G; IFN-alpha 61; LEIF G (IFNA5) interferon [IFN]-alpha 6; IFN-alpha K; IFN-alpha 54; LEIF K (IFNA6) interferon [IFN]-alpha 7; IFN-alpha J; IFN-alpha J1; LEIF J (IFNA7) interferon [IFN]-alpha 8; IFN-alpha B; IFN-alpha B2; LEIF B (IFNA8) interferon [IFN]-omega 1; IFN-alpha II-1 (IFNW1) interferon-alfa

General

interferon

Properties

SIZE: MW = 16-27 kD entity length = 166 aa COMPARTMENT: extracellular compartment SECRETED-BY: macrophage lymphoblast

Database Correlations

OMIM 147660

References

  1. Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: 1589908
  2. Kwon D Rogue antibodies involved in almost one-fifth of COVID deaths. Nature News. August 31, 2021 https://www.nature.com/articles/d41586-021-02337-5 - Bastard P, Gervais A, Le Voyer T et al Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths, Sci Immunol. 2021 Aug 19;6(62):eabl4340. PMID: 34413139