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intelectin-1 (intestinal lactoferrin receptor, galactofuranose-binding lectin, endothelial lectin HL-1, omentin, ITLN1, INTL, ITLN, LFR, UNQ640/PRO1270)
Function:
- role in the defense system against microorganisms (putative)
- may specifically recognize carbohydrate chains of pathogens & bacterial components containing galactofuranosyl residues (Ca+2-dependent)
- role in iron metabolism (putative)
Structure:
- homotrimer, disulfide-linked
- N-glycosylated
- contains 1 fibrinogen C-terminal domain
Compartment:
- cell membrane, GPI-anchor
- secreted
Expression:
- expressed in the small intestine > heart, testis, colon, salivary gland, skeletal muscle, pancreas, thyroid > uterus, spleen, prostate, lymph node, thymus
- found in fetal small intestine & thymus
Genetics:
- two mouse genes Itln1a & Itln1b are paralogs of human ITLN1
General
glypiated protein
Properties
SIZE: MW = 35 kD
entity length = 313 aa
COMPARTMENT: plasma membrane
CELL-REGION: apical region
CELL: epithelial cell
MOTIF: signal sequence {1-18}
Fibrinogen C-terminal {36-209}
MOTIF: N-glycosylation site {N163}
glycosyl phosphatidylinositol [GPI] membrane anchor {N298}
Database Correlations
UniProt Q8WWA0
Pfam PF00147
References
UniProt :accession Q8WWA0