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integrin alpha-V/beta-5
Function:
- receptor for fibronectin
- recognizes the sequence R-G-D in its ligand
Structure:
- subunits: integrin alpha-V, integrin beta-5
Compartment: membrane
General
integrin
Properties
COMPARTMENT: plasma membrane
MOTIF: focal adhesion site
transmembrane domain
SUBUNITS: integrin alpha-V
MOTIF: signal sequence {1-30}
FG-GAP {46-108}
MOTIF: N-glycosylation site {N74}
cysteine residue {C89}
MODIFICATION: cysteine residue {C97}
cysteine residue {C97}
MODIFICATION: cysteine residue {C89}
FG-GAP {113-178}
MOTIF: cysteine residue {C138}
MODIFICATION: cysteine residue {C158}
cysteine residue {C158}
MODIFICATION: cysteine residue {C138}
cysteine residue {C172}
MODIFICATION: cysteine residue {C185}
FG-GAP {179-236}
MOTIF: cysteine residue {C185}
MODIFICATION: cysteine residue {C172}
FG-GAP {249-302}
MOTIF: Ca+2-binding site
SITE: 260-268
N-glycosylation site {N290}
N-glycosylation site {N296}
FG-GAP {303-362}
MOTIF: Ca+2-binding site
SITE: 314-322
FG-GAP {367-427}
MOTIF: Ca+2-binding site
SITE: 379-387
FG-GAP {432-483}
MOTIF: Ca+2-binding site
SITE: 443-451
N-glycosylation site {N488}
cysteine residue {C491}
MODIFICATION: cysteine residue {C502}
cysteine residue {C502}
MODIFICATION: cysteine residue {C491}
cysteine residue {C508}
MODIFICATION: cysteine residue {C565}
N-glycosylation site {N554}
cysteine residue {C565}
MODIFICATION: cysteine residue {C508}
N-glycosylation site {N615}
cysteine residue {C626}
MODIFICATION: cysteine residue {C632}
cysteine residue {C632}
MODIFICATION: cysteine residue {C626}
cysteine residue {C698}
MODIFICATION: cysteine residue {C711}
N-glycosylation site {N704}
cysteine residue {C711}
MODIFICATION: cysteine residue {C698}
N-glycosylation site {N835}
N-glycosylation site {N851}
cysteine residue {C852}
MODIFICATION: cysteine residue {C-INTERCHAIN}
N-glycosylation site {N874}
cysteine residue {C904}
MODIFICATION: cysteine residue {C909}
cysteine residue {C909}
MODIFICATION: cysteine residue {C904}
N-glycosylation site {N945}
N-glycosylation site {N973}
N-glycosylation site {N980}
transmembrane domain {993-1016}
GFFKR {1019-1023}
integrin-beta 5
MOTIF: signal sequence {1-23}
PSI {27-76}
MOTIF: cysteine residue {C28}
MODIFICATION: cysteine residue {C463}
cysteine residue {C36}
MODIFICATION: cysteine residue {C46}
cysteine residue {C39}
MODIFICATION: cysteine residue {C75}
cysteine residue {C46}
MODIFICATION: cysteine residue {C36}
cysteine residue {C49}
MODIFICATION: cysteine residue {C64}
cysteine residue {C64}
MODIFICATION: cysteine residue {C49}
cysteine residue {C75}
MODIFICATION: cysteine residue {C39}
VWFA domain {136-378}
MOTIF: cysteine residue {C202}
MODIFICATION: cysteine residue {C211}
cysteine residue {C211}
MODIFICATION: cysteine residue {C202}
cysteine residue {C259}
MODIFICATION: cysteine residue {C300}
cysteine residue {C300}
MODIFICATION: cysteine residue {C259}
N-glycosylation site {N347}
cysteine residue {C401}
MODIFICATION: cysteine residue {C413}
cysteine residue {C413}
MODIFICATION: cysteine residue {C401}
cysteine residue {C433}
MODIFICATION: cysteine residue {C682}
N-glycosylation site {N460}
cysteine residue {C461}
MODIFICATION: cysteine residue {C465}
cysteine residue {C463}
MODIFICATION: cysteine residue {C28}
Cysteine-rich tandem repeats {465-630}
MOTIF: consensus repeat {465-512}
cysteine residue {C465}
MODIFICATION: cysteine residue {C461}
cysteine residue {C476}
MODIFICATION: cysteine residue {C487}
N-glycosylation site {N477}
cysteine residue {C484}
MODIFICATION: cysteine residue {C522}
cysteine residue {C487}
MODIFICATION: cysteine residue {C476}
cysteine residue {C489}
MODIFICATION: cysteine residue {C498}
cysteine residue {C498}
MODIFICATION: cysteine residue {C489}
cysteine residue {C500}
MODIFICATION: cysteine residue {C513}
N-glycosylation site {N505}
consensus repeat {513-554}
cysteine residue {C513}
MODIFICATION: cysteine residue {C500}
cysteine residue {C522}
MODIFICATION: cysteine residue {C484}
cysteine residue {C528}
MODIFICATION: cysteine residue {C533}
cysteine residue {C530}
MODIFICATION: cysteine residue {C563}
cysteine residue {C533}
MODIFICATION: cysteine residue {C528}
cysteine residue {C535}
MODIFICATION: cysteine residue {C548}
cysteine residue {C548}
MODIFICATION: cysteine residue {C535}
cysteine residue {C550}
MODIFICATION: cysteine residue {C555}
N-glycosylation site {N552}
consensus repeat {555-593}
cysteine residue {C555}
MODIFICATION: cysteine residue {C550}
cysteine residue {C563}
MODIFICATION: cysteine residue {C530}
cysteine residue {C569}
MODIFICATION: cysteine residue {C574}
cysteine residue {C571}
MODIFICATION: cysteine residue {C602}
cysteine residue {C574}
MODIFICATION: cysteine residue {C569}
cysteine residue {C576}
MODIFICATION: cysteine residue {C585}
cysteine residue {C585}
MODIFICATION: cysteine residue {C576}
N-glycosylation site {N586}
cysteine residue {C587}
MODIFICATION: cysteine residue {C594}
consensus repeat {594-630}
cysteine residue {C594}
MODIFICATION: cysteine residue {C587}
cysteine residue {C602}
MODIFICATION: cysteine residue {C571}
cysteine residue {C608}
MODIFICATION: cysteine residue {C613}
cysteine residue {C610}
MODIFICATION: cysteine residue {C657}
cysteine residue {C613}
MODIFICATION: cysteine residue {C608}
cysteine residue {C615}
MODIFICATION: cysteine residue {C625}
cysteine residue {C625}
MODIFICATION: cysteine residue {C615}
cysteine residue {C628}
MODIFICATION: cysteine residue {C631}
cysteine residue {C631}
MODIFICATION: cysteine residue {C628}
cysteine residue {C635}
MODIFICATION: cysteine residue {C644}
cysteine residue {C641}
MODIFICATION: cysteine residue {C714}
cysteine residue {C644}
MODIFICATION: cysteine residue {C635}
N-glycosylation site {N654}
cysteine residue {C657}
MODIFICATION: cysteine residue {C610}
cysteine residue {C661}
MODIFICATION: cysteine residue {C690}
cysteine residue {C682}
MODIFICATION: cysteine residue {C433}
cysteine residue {C690}
MODIFICATION: cysteine residue {C661}
N-glycosylation site {N705}
cysteine residue {C714}
MODIFICATION: cysteine residue {C641}
transmembrane domain {720-742}
References
UniProt :accession P05107
Components
CD51 (integrin alpha-V, vitronectin receptor alpha chain, ITGAV, MSK8, VNRA)
integrin-beta 5 (ITGB5)