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integrin alpha-V/beta-3

Function: - receptor for ADAM23 Structure: - subunits: integrin alpha-V, integrin beta-3 Compartment: membrane Comparative Biology: - in vitro & in mice, integrin alpha-V/beta-3 is a marker of breast carcinoma, lung carcinoma, & pancreatic carcinoma - such cells have stem-like properties & are highly resistant to receptor tyrosine kinase inhibitors such as erlotinib - in the unbound state, integrin alpha-V/beta-3 recruits KRAS & RalB to the tumor cell plasma membrane, leading to activation of TBK1 & NF-kappaB

General

integrin

Properties

COMPARTMENT: plasma membrane MOTIF: focal adhesion site transmembrane domain SUBUNITS: integrin alpha-V MOTIF: signal sequence {1-30} FG-GAP {46-108} MOTIF: N-glycosylation site {N74} cysteine residue {C89} MODIFICATION: cysteine residue {C97} cysteine residue {C97} MODIFICATION: cysteine residue {C89} FG-GAP {113-178} MOTIF: cysteine residue {C138} MODIFICATION: cysteine residue {C158} cysteine residue {C158} MODIFICATION: cysteine residue {C138} cysteine residue {C172} MODIFICATION: cysteine residue {C185} FG-GAP {179-236} MOTIF: cysteine residue {C185} MODIFICATION: cysteine residue {C172} FG-GAP {249-302} MOTIF: Ca+2-binding site SITE: 260-268 N-glycosylation site {N290} N-glycosylation site {N296} FG-GAP {303-362} MOTIF: Ca+2-binding site SITE: 314-322 FG-GAP {367-427} MOTIF: Ca+2-binding site SITE: 379-387 FG-GAP {432-483} MOTIF: Ca+2-binding site SITE: 443-451 N-glycosylation site {N488} cysteine residue {C491} MODIFICATION: cysteine residue {C502} cysteine residue {C502} MODIFICATION: cysteine residue {C491} cysteine residue {C508} MODIFICATION: cysteine residue {C565} N-glycosylation site {N554} cysteine residue {C565} MODIFICATION: cysteine residue {C508} N-glycosylation site {N615} cysteine residue {C626} MODIFICATION: cysteine residue {C632} cysteine residue {C632} MODIFICATION: cysteine residue {C626} cysteine residue {C698} MODIFICATION: cysteine residue {C711} N-glycosylation site {N704} cysteine residue {C711} MODIFICATION: cysteine residue {C698} N-glycosylation site {N835} N-glycosylation site {N851} cysteine residue {C852} MODIFICATION: cysteine residue {C-INTERCHAIN} N-glycosylation site {N874} cysteine residue {C904} MODIFICATION: cysteine residue {C909} cysteine residue {C909} MODIFICATION: cysteine residue {C904} N-glycosylation site {N945} N-glycosylation site {N973} N-glycosylation site {N980} transmembrane domain {993-1016} GFFKR {1019-1023} integrin-beta 3 MOTIF: signal sequence {1-26} cysteine residue {C31} MODIFICATION: cysteine residue {C461} cysteine residue {C39} MODIFICATION: cysteine residue {C49} cysteine residue {C42} MODIFICATION: cysteine residue {C75} cysteine residue {C49} MODIFICATION: cysteine residue {C39} cysteine residue {C52} MODIFICATION: cysteine residue {C64} cysteine residue {C64} MODIFICATION: cysteine residue {C52} cysteine residue {C75} MODIFICATION: cysteine residue {C42} N-glycosylation site {N125} VWFA domain {135-377} MOTIF: cysteine residue {C203} MODIFICATION: cysteine residue {C210} cysteine residue {C210} MODIFICATION: cysteine residue {C203} cysteine residue {C258} MODIFICATION: cysteine residue {C299} cysteine residue {C299} MODIFICATION: cysteine residue {C258} N-glycosylation site {N346} N-glycosylation site {N397} cysteine residue {C400} MODIFICATION: cysteine residue {C412} cysteine residue {C412} MODIFICATION: cysteine residue {C400} cysteine residue {C432} MODIFICATION: cysteine residue {C681} cysteine residue {C459} MODIFICATION: cysteine residue {C463} cysteine residue {C461} MODIFICATION: cysteine residue {C31} Cysteine-rich tandem repeats {463-629} MOTIF: consensus repeat {463-511} cysteine residue {C463} MODIFICATION: cysteine residue {C459} cysteine residue {C474} MODIFICATION: cysteine residue {C486} N-glycosylation site {N478} cysteine residue {C483} MODIFICATION: cysteine residue {C521} cysteine residue {C486} MODIFICATION: cysteine residue {C474} cysteine residue {C488} MODIFICATION: cysteine residue {C497} cysteine residue {C497} MODIFICATION: cysteine residue {C488} cysteine residue {C499} MODIFICATION: cysteine residue {C512} consensus repeat {512-553} cysteine residue {C512} MODIFICATION: cysteine residue {C499} cysteine residue {C521} MODIFICATION: cysteine residue {C483} cysteine residue {C527} MODIFICATION: cysteine residue {C532} cysteine residue {C529} MODIFICATION: cysteine residue {C562} cysteine residue {C532} MODIFICATION: cysteine residue {C527} cysteine residue {C534} MODIFICATION: cysteine residue {C547} cysteine residue {C547} MODIFICATION: cysteine residue {C534} cysteine residue {C549} MODIFICATION: cysteine residue {C554} consensus repeat {554-592} cysteine residue {C554} MODIFICATION: cysteine residue {C549} cysteine residue {C562} MODIFICATION: cysteine residue {C529} cysteine residue {C568} MODIFICATION: cysteine residue {C573} cysteine residue {C570} MODIFICATION: cysteine residue {C601} cysteine residue {C573} MODIFICATION: cysteine residue {C568} cysteine residue {C575} MODIFICATION: cysteine residue {C584} cysteine residue {C584} MODIFICATION: cysteine residue {C575} N-glycosylation site {N585} cysteine residue {C586} MODIFICATION: cysteine residue {C593} consensus repeat {593-629} cysteine residue {C593} MODIFICATION: cysteine residue {C586} cysteine residue {C601} MODIFICATION: cysteine residue {C570} cysteine residue {C607} MODIFICATION: cysteine residue {C612} cysteine residue {C609} MODIFICATION: cysteine residue {C657} cysteine residue {C612} MODIFICATION: cysteine residue {C607} cysteine residue {C614} MODIFICATION: cysteine residue {C624} cysteine residue {C624} MODIFICATION: cysteine residue {C614} cysteine residue {C627} MODIFICATION: cysteine residue {C630} cysteine residue {C630} MODIFICATION: cysteine residue {C627} cysteine residue {C634} MODIFICATION: cysteine residue {C643} cysteine residue {C640} MODIFICATION: cysteine residue {C713} cysteine residue {C643} MODIFICATION: cysteine residue {C634} cysteine residue {C657} MODIFICATION: cysteine residue {C609} cysteine residue {C661} MODIFICATION: cysteine residue {C689} N-glycosylation site {N680} cysteine residue {C681} MODIFICATION: cysteine residue {C432} cysteine residue {C689} MODIFICATION: cysteine residue {C661} cysteine residue {C713} MODIFICATION: cysteine residue {C640} transmembrane domain {719-741} Tyr phosphorylation site {Y773} Thr phosphorylation site {T779} Tyr phosphorylation site {Y785}

References

  1. UniProt :accession P05107
  2. Researchers Pinpoint Cancer Stem Cell Role in Drug Resistance. Genetic Engineering & Biotechnology News. April 21, 2014 cites: Nature Cell Biology publication http://www.genengnews.com/gen-news-highlights/researchers-pinpoint-cancer-stem-cell-role-in-drug-resistance/81249766/

Components

CD51 (integrin alpha-V, vitronectin receptor alpha chain, ITGAV, MSK8, VNRA) CD61 (integrin-beta 3, platelet membrane glycoprotein IIIA, GPIIIA, ITGB3, GP3A)