very late antigen 6 (VLA-6, integrin alpha-6/beta-1)

Function: - platelet laminin receptor

Properties

COMPARTMENT: plasma membrane CELL: T-cell MOTIF: focal adhesion site glycosylation site membrane region SUBUNITS: integrin alpha-6 MOTIF: signal sequence {1-23} FG-GAP {42-79} MOTIF: N-glycosylation site {N78} cysteine residue {C86} MODIFICATION: cysteine residue {C94} cysteine residue {C94} MODIFICATION: cysteine residue {C86} FG-GAP {113-145} MOTIF: cysteine residue {C131} MODIFICATION: cysteine residue {C154} cysteine residue {C154} MODIFICATION: cysteine residue {C131} cysteine residue {C175} MODIFICATION: cysteine residue {C188} FG-GAP {185-217} MOTIF: cysteine residue {C188} MODIFICATION: cysteine residue {C175} N-glycosylation site {N223} FG-GAP {295-331} MOTIF: N-glycosylation site {N323} FG-GAP {353-391} MOTIF: Ca+2-binding site SITE: 363-371 N-glycosylation site {N409} FG-GAP {414-450} MOTIF: Ca+2-binding site SITE: 425-433 FG-GAP {469-509} MOTIF: Ca+2-binding site SITE: 480-488 cysteine residue {C528} MODIFICATION: cysteine residue {C535} cysteine residue {C535} MODIFICATION: cysteine residue {C528} cysteine residue {C541} MODIFICATION: cysteine residue {C601} kxgffkr NAME: kxgffkr SITE: cytoplasmic domain FOR-BINDING-OF: calreticulin FORM: kxgffkr cysteine residue {C601} MODIFICATION: cysteine residue {C541} cysteine residue {C665} MODIFICATION: cysteine residue {C671} cysteine residue {C671} MODIFICATION: cysteine residue {C665} cysteine residue {C765} MODIFICATION: cysteine residue {C776} N-glycosylation site {N770} cysteine residue {C776} MODIFICATION: cysteine residue {C765} N-glycosylation site {N787} cysteine residue {C920} MODIFICATION: cysteine residue {C-INTERCHAIN} N-glycosylation site {N930} N-glycosylation site {N966} cysteine residue {C973} MODIFICATION: cysteine residue {C978} cysteine residue {C978} MODIFICATION: cysteine residue {C973} N-glycosylation site {N997} transmembrane domain {1051-1076} HPS5 interaction {1077-1083} MOTIF: GFFKR {1079-1083} integrin-beta 1 MOTIF: signal sequence {1-20} cysteine residue {C27} MODIFICATION: cysteine residue {C464} cysteine residue {C35} MODIFICATION: cysteine residue {C45} cysteine residue {C38} MODIFICATION: cysteine residue {C75} cysteine residue {C45} MODIFICATION: cysteine residue {C35} cysteine residue {C48} MODIFICATION: cysteine residue {C64} N-glycosylation site {N50} cysteine residue {C64} MODIFICATION: cysteine residue {C48} cysteine residue {C75} MODIFICATION: cysteine residue {C38} N-glycosylation site {N94} N-glycosylation site {N97} VWFA domain {140-378} MOTIF: cysteine residue {C207} MODIFICATION: cysteine residue {C213} N-glycosylation site {N212} cysteine residue {C213} MODIFICATION: cysteine residue {C207} cysteine residue {C261} MODIFICATION: cysteine residue {C301} N-glycosylation site {N269} cysteine residue {C301} MODIFICATION: cysteine residue {C261} N-glycosylation site {N363} cysteine residue {C401} MODIFICATION: cysteine residue {C415} N-glycosylation site {N406} cysteine residue {C415} MODIFICATION: cysteine residue {C401} N-glycosylation site {N417} cysteine residue {C435} MODIFICATION: cysteine residue {C691} cysteine residue {C462} MODIFICATION: cysteine residue {C466} cysteine residue {C464} MODIFICATION: cysteine residue {C27} Cysteine-rich tandem repeats {466-635} MOTIF: I {466-515} cysteine residue {C466} MODIFICATION: cysteine residue {C462} cysteine residue {C477} MODIFICATION: cysteine residue {C489} N-glycosylation site {N481} cysteine residue {C486} MODIFICATION: cysteine residue {C525} cysteine residue {C489} MODIFICATION: cysteine residue {C477} cysteine residue {C491} MODIFICATION: cysteine residue {C500} cysteine residue {C500} MODIFICATION: cysteine residue {C491} cysteine residue {C502} MODIFICATION: cysteine residue {C516} II {516-559} cysteine residue {C516} MODIFICATION: cysteine residue {C502} N-glycosylation site {N520} cysteine residue {C525} MODIFICATION: cysteine residue {C486} cysteine residue {C531} MODIFICATION: cysteine residue {C536} cysteine residue {C533} MODIFICATION: cysteine residue {C568} cysteine residue {C536} MODIFICATION: cysteine residue {C531} cysteine residue {C538} MODIFICATION: cysteine residue {C553} cysteine residue {C553} MODIFICATION: cysteine residue {C538} cysteine residue {C555} MODIFICATION: cysteine residue {C560} III {560-598} cysteine residue {C560} MODIFICATION: cysteine residue {C555} cysteine residue {C568} MODIFICATION: cysteine residue {C533} cysteine residue {C574} MODIFICATION: cysteine residue {C579} cysteine residue {C576} MODIFICATION: cysteine residue {C607} cysteine residue {C579} MODIFICATION: cysteine residue {C574} cysteine residue {C581} MODIFICATION: cysteine residue {C590} N-glycosylation site {N584} cysteine residue {C590} MODIFICATION: cysteine residue {C581} cysteine residue {C592} MODIFICATION: cysteine residue {C599} IV {599-635} cysteine residue {C599} MODIFICATION: cysteine residue {C592} cysteine residue {C607} MODIFICATION: cysteine residue {C576} cysteine residue {C613} MODIFICATION: cysteine residue {C618} cysteine residue {C615} MODIFICATION: cysteine residue {C661} cysteine residue {C618} MODIFICATION: cysteine residue {C613} cysteine residue {C620} MODIFICATION: cysteine residue {C630} cysteine residue {C630} MODIFICATION: cysteine residue {C620} cysteine residue {C633} MODIFICATION: cysteine residue {C636} cysteine residue {C636} MODIFICATION: cysteine residue {C633} cysteine residue {C640} MODIFICATION: cysteine residue {C649} cysteine residue {C646} MODIFICATION: cysteine residue {C723} cysteine residue {C649} MODIFICATION: cysteine residue {C640} cysteine residue {C661} MODIFICATION: cysteine residue {C615} cysteine residue {C665} MODIFICATION: cysteine residue {C699} N-glycosylation site {N669} cysteine residue {C691} MODIFICATION: cysteine residue {C435} cysteine residue {C699} MODIFICATION: cysteine residue {C665} cysteine residue {C723} MODIFICATION: cysteine residue {C646} transmembrane domain {729-751} Tyr phosphorylation site {Y783}

References

PROSITE :accession PS00242

Components

CD29; integrin-beta 1; fibronectin receptor beta; platelet glycoprotein IIa; VLA-4 beta (ITGB1, FNRB, MDF2, MSK12) CD49f (integrin alpha-6, integrin alpha-F, ITGA6)