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insulin-resistant diabetes mellitus with acanthosis nigricans
Pathology:
- defective insulin receptor (genetic) {type A}
- circulating autoantibodies against the insulin receptor {type B}
Genetics:
- associated with defects in insulin receptor (INSR) {type A}
Clinical manifestations:
- severe insulin resistance (manifested by marked hyperinsulinemia & a failure to respond to exogenous insulin)
- acanthosis nigricans
- ovarian hyperandrogenism in adolescent female subjects
- women frequently present with
a) hirsutism
b) acne
c) amenorrhea or oligomenorrhea
d) virilization
Laboratory:
- serum glucose (high)
- serum insulin (high)
General
diabetes mellitus type 2 (insulin-resistant)
syndrome
Database Correlations
OMIM 610549
References
UniProt :accession P06213