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insulinase, insulysin, insulin protease or insulin-degrading enzyme
Function:
- pepetidase/ protease
- substrates include:
- insulin
- glucagon
- atrial natriuretic factor
- TGF-alpha
- beta-endorphin
- amylin
- amyloid A4 peptide.
Compartment:
- cytosol
- peroxisomes
- extracellular fluid
- plasma membrane
- internal membranes.
Expression:
- microglia
- liver
- neurons (cell surface) [2]
General
zinc metalloprotease
Properties
SIZE: MW = 110 kD
COMPARTMENT: cytoplasm
MOTIF: active site
MOTIF: Zn+2-binding site
EFFECTOR-BOUND: Zn+2
MOTIF: histidine residue (2)
glutamate residue
cysteine residue (14)
Database Correlations
OMIM 146680
UniProt P14735
ENZYME 3.4.99.45
References
- Selkoe DJ.
Clearing the brain's amyloid cobwebs.
Neuron. 2001 Oct 25;32(2):177-80. Review.
PMID: 11683988
- Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V,
Rosner MR, Selkoe DJ.
Neurons regulate extracellular levels of amyloid beta-protein
via proteolysis by insulin-degrading enzyme.
J Neurosci. 2000 Mar 1;20(5):1657-65.
PMID: 10684867
{from Selkoe's group}