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inositol-1,2,3,4,5,6-hexaphosphate (IP6, phytic acid)

Inositol-1,3,4,5,6-pentaphosphate & inositol hexaphosphate [IP6] comprise the bulk of the inositol phosphate content of mammalian cells. Function: 1) mRNA export 2) nonhomologous end-joining 3) endocytosis 4) ion channel regulation 5) protects cells from TNF-alpha-induced apoptosis 6) may have anti-carcinogenic properties [2-6] Notes: - Marketed as Inositol & Ca+2, Mg+2 IP6 (InoCell) [7]

Interactions

molecular events

Related

phytate in serum/plasma

General

inositol phosphate

Properties

COMPARTMENT: cytoplasm PHOSPHORYLATION: 4-OH

Database Correlations

PUBCHEM correlations

References

  1. Menniti FS, Oliver KG, Putney JW Jr, Shears SB. Inositol phosphates and cell signaling: new views of InsP5 and InsP6. Trends Biochem Sci. 1993 Feb;18(2):53-6. Review. PMID: 8387704
  2. Somasundar P, Riggs DR, Jackson BJ, Cunningham C, Vona-Davis L, McFadden DW. Inositol Hexaphosphate (IP6): A Novel Treatment for Pancreatic Cancer(1). J Surg Res. 2005 Jun 15;126(2):199-203. PMID: 15919420 - Agarwal C, Dhanalakshmi S, Singh RP, Agarwal R. Inositol hexaphosphate inhibits growth and induces G1 arrest and apoptotic death of androgen-dependent human prostate carcinoma LNCaP cells. Neoplasia. 2004 Sep-Oct;6(5):646-59. PMID: 15548374
  3. Vucenik I, Ramakrishna G, Tantivejkul K, Anderson LM, Ramljak D. Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation. Breast Cancer Res Treat. 2005 May;91(1):35-45. PMID: 15868430
  4. Vucenik I, Passaniti A, Vitolo MI, Tantivejkul K, Eggleton P, Shamsuddin AM. Anti-angiogenic activity of inositol hexaphosphate (IP6). Carcinogenesis. 2004 Nov;25(11):2115-23. Epub 2004 Aug 5. PMID: 15297368
  5. Tantivejkul K, Vucenik I, Shamsuddin AM. Inositol hexaphosphate (IP6) inhibits key events of cancer metastasis: I. In vitro studies of adhesion, migration and invasion of MDA-MB 231 human breast cancer cells. Anticancer Res. 2003 Sep-Oct;23(5A):3671-9. PMID: 14666663 - Tantivejkul K, Vucenik I, Shamsuddin AM. Inositol hexaphosphate (IP6) inhibits key events of cancer metastasis: II. Effects on integrins and focal adhesions. Anticancer Res. 2003 Sep-Oct;23(5A):3681-9. PMID: 14666664
  6. Vucenik I, Shamsuddin AM. Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic. J Nutr. 2003 Nov;133(11 Suppl 1):3778S-3784S. Review. PMID: 14608114
  7. InoCell http://www.inocell.com/index.html
  8. UniProt :accession Q9H8X2